HBZ and its roles in HTLV-1 oncogenesis
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منابع مشابه
HBZ and its roles in HTLV-1 oncogenesis
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, ...
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Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and chronic inflammatory diseases. HTLV-1 bZIP factor (HBZ) is transcribed as an antisense transcript of the HTLV-1 provirus. Among the HTLV-1-encoded viral genes, HBZ is the only gene that is constitutively expressed in all ATL cases. Recent studies have demonstrated that HBZ plays an essential role in oncogenesis b...
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1 Equipe Oncogenèse Rétrovirale, CIRI Inserm U1111-CNRS UMR5308, Paris, France 2 Equipe Labellisée “Ligue Nationale Contre le Cancer”, CIRI Inserm U1111-CNRS UMR5308, Paris, France 3 International Center for Research in Infectiology, INSERM U1111 CNRS UMR5308, Paris, France 4 Ecole Normale Supérieure de Lyon, Lyon, France 5 Université Lyon 1, Lyon, France 6 Laboratory of Tumor Cell Biology, Dep...
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Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus that has infected 10-15 million people worldwide. After a long latency, 3-5% of infected individuals will develop either a severe malignancy of CD4+ T cells, known as Adult T-cell Leukemia (ATL) or a chronic and progressive inflammatory disease of the nervous system designated Tropical Spastic Paraparesis/HTLV-1-Associ...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2012
ISSN: 1664-302X
DOI: 10.3389/fmicb.2012.00247